@misc{franke_influence_of_2009, 
author={Franke, R.P.,Fuhrmann, R.,Hiebl, B.,Jung, F.},
title={Influence of radiographic contrast media on the secretion of vasoactive substances by primary human umbilical venous endothelial cells (HUVEC): Prospective, controlled, in vitro comparative study},
year={2009},
howpublished = {journal article},
doi = {https://doi.org/10.3233/CH-2009-1233},
abstract = {Besides the desirable effect of roentgen ray absorption radiographic contrast media (RCM) can also have varying adverse effects. Under discussion, as a possible cause, are microcirculatory disorders resulting from morphological alterations in erythrocytes and endothelial cells.,Therefore, the contrast media-induced release of vasoactive substances (prostacyclin, endothelin-1, and nitric oxide (NO)) from human endothelial cells (HUVEC) induced by two commercially available RCMs (Iodixanol 320, Iomeprol 350) was tested in a controlled in-vitro study.,The results show that RCMs lead to endothelial cell trauma in vitro, which is apparent in the release of prostacyclin and endothelin-1, while NO release was not affected. The endothelin-1 release after incubation with Iodixanol was similar to the release in the control cultures. In comparison, lower endothelin-1 levels were measured in the cultures incubated with Iomeprol at all 3 time points indicating a more significant cell trauma. Prostacyclin release – also an indicator of traumatization of endothelial cells – increased after addition of both contrast agents. The highest release was found after incubation with Iomeprol 350.},
note = {Online available at: \url{https://doi.org/10.3233/CH-2009-1233} (DOI). Franke, R.; Fuhrmann, R.; Hiebl, B.; Jung, F.: Influence of radiographic contrast media on the secretion of vasoactive substances by primary human umbilical venous endothelial cells (HUVEC): Prospective, controlled, in vitro comparative study. Clinical Hemorheology and Microcirculation. 2009. vol. 43, no. 1-2, 181-187. DOI: 10.3233/CH-2009-1233}}