@misc{park_dobutamine_stress_2008, 
author={Park, J.-W.,Leithaeuser, B.,Vrsansky, M.,Jung, F.},
title={Dobutamine stress magnetocardiography for the detection of significant coronary artery stenoses – A prospective study in comparison with simultaneous 12-lead electrocardiography},
year={2008},
howpublished = {journal article},
doi = {https://doi.org/10.3233/CH-2008-1064},
abstract = {Background: Exercise electrocardiography is an imperfect test for the detection of coronary artery disease (CAD). Magnetocardiography detects cardiac electrical disturbances associated with myocardial ischemia. We prospectively investigated the accuracy of high-dose dobutamine stress magnetocardiography (DS-MCG) and simultaneous electrocardiography (DS-ECG) for the detection of significant CAD.,Methods: 100 patients with an intermediate pre-test probability for CAD underwent DS-MCG using a multichannel magnetometer prior to invasive coronary angiography. Patients were examined at rest and during a standard dobutamine–atropine scheme. Significant reduction of epicardial current strength/density during stress, reconstructed from the magnetic field map and superposed on a virtual heart model indicates myocardial ischemia. A 12-lead DS-ECG was recorded simultaneously. Significant coronary artery stenosis was defined as ≥70% of lumen reduction.,Results: Without β-blocker all 100 patients reached the targeted heart rate. The image quality of DS-MCG and DS-ECG was sufficient for analysis in all patients. In 19 patients CAD was ruled out angiographically. Thirty two or seven patients revealed coronary artery stenoses of 30–49% or of 50–69%, respectively. In 42 patients we found significant stenoses of ≥70%. In 41 of these patients DS-MCG revealed myocardial ischemia. The sensitivity of DS-MCG and DS-ECG for the detection of significant coronary artery stenosis was 97.6% and 26.2%, the specificity of DS-MCG and DS-ECG 82.8% and 82.8%, respectively.},
note = {Online available at: \url{https://doi.org/10.3233/CH-2008-1064} (DOI). Park, J.; Leithaeuser, B.; Vrsansky, M.; Jung, F.: Dobutamine stress magnetocardiography for the detection of significant coronary artery stenoses – A prospective study in comparison with simultaneous 12-lead electrocardiography. Clinical Hemorheology and Microcirculation. 2008. vol. 39, no. 1-4, 21-32. DOI: 10.3233/CH-2008-1064}}