@misc{abell_investigation_into_2007, 
author={Abell, A.D.,Jones, M.A.,Neffe, A.T.,Aitken, S.G.,Cain, T.P.,Payne, R.J.,McNabb, S.B.,Coxon, J.M.,Stuart, B.G.,Pearson, D.,Lee, H.Y.-Y.,Morton, J.D.},
title={Investigation into the P3 Binding Domain of m-Calpain Using Photoswitchable Diazo- and Triazene-dipeptide Aldehydes: New Anticataract Agents},
year={2007},
howpublished = {journal article},
doi = {https://doi.org/10.1021/jm061455n},
abstract = {The photoswitchable N-terminal diazo and triazene-dipeptide aldehydes 8a-d, 10a,b, and 17a,b present predominantly as the (E)-isomer, which purportedly binds deep in the S3 pocket of calpain. All compounds are potent inhibitors of m-calpain, with 8b being the most active (IC50 of 35 nM). The diazo-containing inhibitors 8a, 8c, and 10a were irradiated at 340 nm to give a photostationary state enriched in the (Z)-isomer, and in all cases, these were less active. The most water soluble triazene 17a (IC50 of 90 nM) retards calpain-induced cataract formation in lens culture.},
note = {Online available at: \url{https://doi.org/10.1021/jm061455n} (DOI). Abell, A.; Jones, M.; Neffe, A.; Aitken, S.; Cain, T.; Payne, R.; McNabb, S.; Coxon, J.; Stuart, B.; Pearson, D.; Lee, H.; Morton, J.: Investigation into the P3 Binding Domain of m-Calpain Using Photoswitchable Diazo- and Triazene-dipeptide Aldehydes: New Anticataract Agents. Journal of Medicinal Chemistry. 2007. vol. 50, no. 12, 2916-2920. DOI: 10.1021/jm061455n}}